PAEA Surgery End Of Rotation (EOR) Practice Exam

Which cells are the origin of carcinoid tumors in the GI tract?

1. Enterochromaffin cells

2. Kulchitsky cells

3. Pancreatic cells

4. Both Enterochromaffin and Kulchitsky cells

The correct answer is: Both Enterochromaffin and Kulchitsky cells

Carcinoid tumors in the gastrointestinal (GI) tract primarily originate from neuroendocrine cells, specifically the enterochromaffin cells, which are found in the mucosa of the GI tract. These cells produce serotonin and other neuroendocrine substances. Kulchitsky cells are another type of neuroendocrine cell found predominantly in the gastrointestinal epithelium. Both enterochromaffin cells and Kulchitsky cells share a common lineage and functional characteristics, as they are involved in the neuroendocrine system of the gut. The correct choice reflects the understanding that carcinoid tumors can arise from both types of cells, thus giving rise to the designation that both can be considered origins of these tumors in the context of neuroendocrine neoplasms. This dual origin underscores the heterogeneous nature of carcinoid tumors, highlighting that they stem from specialized cells within the gut capable of secreting various hormones and neurotransmitters. Understanding the dual origins of these cells aids in comprehending the biological behavior and clinical implications of carcinoid tumors in patients.