PAEA Surgery End Of Rotation (EOR) Practice Exam

What are the most common drugs causing drug-induced urticarial?

1. NSAIDs

2. Penicillins

3. Antidepressants

4. Antihistamines

The correct answer is: Penicillins

Drug-induced urticaria, which is characterized by the sudden appearance of wheals and hives, can be triggered by various medications. Penicillins are often identified as one of the most common culprits for inducing urticarial reactions. This class of antibiotics is known for its potential to elicit hypersensitivity reactions in susceptible individuals, which can manifest as urticaria. The mechanism behind penicillin-induced urticaria typically involves an immune-mediated response. In some patients, the immune system incorrectly identifies penicillins as harmful substances, leading to the release of histamine and other mediators from mast cells and basophils. This release is responsible for the classic symptoms of urticaria, including itching and the formation of hives. While NSAIDs (nonsteroidal anti-inflammatory drugs) can also cause urticaria and are a recognized source of drug-induced skin reactions, penicillin stands out in terms of its frequent association with hypersensitivity reactions, particularly in those with a history of allergy to beta-lactam antibiotics. Antidepressants and antihistamines, although they may have various side effects and adverse reactions, are not as commonly associated with urticaria compared to penicillins. Therefore, penicill